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Artificial intelligence to improve chemotherapy dosing

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As is well known, chemotherapies are extremely aggressive treatments that are currently used as the most effective solution to try to eradicate cancer.

Given the strong physical impact of this treatment, interest arose in trying to mitigate its effects. Under this motivation, a team from the American Case Western Reserve University developed an AI system to offer a more precise dosage of this therapy.

Less invasive chemotherapy

In this case, they asked the computer to analyze digitized images of tissue samples that had been taken from 439 patients across six hospital systems with a type of head and neck cancer known as human papillomavirus-associated oropharyngeal squamous cell carcinoma. (HPV) (OPCSCC).

Although most others with HPV-driven cancer would still benefit from aggressive treatment, along with patients whose cancer was unrelated to the virus, the researchers said their study revealed that a significant group were receiving more aggressive HPV therapy. what they needed to achieve a favorable outcome.

Doctors can’t easily make that distinction simply by simply looking at tissue scans, the researchers said. Therefore, virtually all patients with these cancers, regardless of whether they are HPV-driven or not, are treated with a full course of chemotherapy and radiation.

“We’ve been overtreating a lot of patients with chemotherapy and radiation that they don’t need because we didn’t have a way to find out which patients would benefit from de-escalation.”said Anant Madabhushi, director of the CCIPD, professor at the Donnell Institute for Biomedical Engineering in the Case School of Engineering and responsible for this study. “We’re saying now we do, and one day doctors could modulate how we care for people and not just give the standard high dose of radiation to everyone who walks in the door.”.

Madabhushi said reducing radiation for these patients could also help decrease “radiotherapy toxicity,” meaning they might experience fewer side effects such as dry mouth, swallowing dysfunction and changes in taste.

“There are already ongoing national clinical trials investigating reducing the intensity of radiotherapy and chemotherapy in patients with HPV-positive oropharyngeal cancer”said Shlomo Koyfman, director of head and neck and skin cancer radiation at the Cleveland Clinic and a collaborator on the study. “However, properly selecting ideal patients for this treatment reduction has been challenging. This image classifier can help us better select patients for these new treatment paradigms”.

The computer program successfully identified a subset of patients who might have benefited from a significantly reduced dose of radiotherapy.

While that analysis was retrospective, meaning the computer analyzed data from patients where the end result was already known, the researchers said their next step could be to test its accuracy in clinical trials.

His research was recently published in the Journal of the National Cancer Institute.

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Tablets

Screen 10.6 inches with a resolution of 2K, 4 speakers, 7700 mAh and two cameras of 8 megapixels. Specifications of inexpensive tablet Lenovo Xiaoxin Pad 2022

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Screen 106 inches with a resolution of 2K 4 speakers

Lenovo will be hosting a big event in China early next week with many new Xiaoxin, Yoga and Legion series laptops and tablets. One of them will be Xiaoxin Pad 2022, and its specifications have already been fully revealed. There are no prices yet, but the hardware platform is far from the top Snapdragon 680, so this device will definitely not be expensive.

Screen 10.6 inches with a resolution of 2K, 4 speakers, 7700 mAh and two cameras of 8 megapixels.  Specifications of inexpensive tablet Lenovo Xiaoxin Pad 2022

Lenovo Xiaoxin Pad 2022 features 10.6-inch 2000 x 1200 pixel 60Hz IPS screen, four speakers, Wi-F 802.11ac and Bluetooth 5.1, USB-C port, standard headphone jack , microSD card slot up to 1 TB. The battery capacity was 7700 mAh, it supports 20 W charging. There are two cameras, the resolution of the front and the main one is the same – 8 megapixels.

Dimensions Lenovo Xiaoxin Pad 2022 – 251.2 x 158.8 x 7.45 mm, weight – 465 grams. The tablet has two memory configurations: 4/64 GB and 6/128 GB. Apparently, this device will not have a version with an LTE modem.

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This is how the 54-megapixel Honor 70 matrix camera shoots. Sample photos

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This is how the 54 megapixel Honor 70 matrix camera shoots

Honor has published on the Web examples of photos taken by the camera of the Honor 70 smartphone – the premiere of models in this line is scheduled for May 30. Photos look good, there is even an image taken in difficult conditions with bright backlight. But there are no examples of night photos yet.

This is how the 54-megapixel Honor 70 matrix camera shoots. Sample photos

This is how the 54-megapixel Honor 70 matrix camera shoots. Sample photos
This is how the 54-megapixel Honor 70 matrix camera shoots. Sample photos

However, will the same 54-megapixel Sony IMX800 1/1.49-inch optical sensor be in every model in the series? Most probably not. It is logical to use it in the top-end Honor 70 Pro and Honor 70 Pro +, while the younger model of the line will obviously use a not so large sensor.

This is how the 54-megapixel Honor 70 matrix camera shoots. Sample photos

With regard to single-chip systems, there is more certainty. The base Honor 70 is assigned the just-announced Snapdragon 7 Gen 1, the Honor 70 Pro will receive the MdeiaTek Dimensity 8000, and the Honor 70 Pro + will use the top-end Dimensity 9000 SoC. Older models will also support 100W fast wired charging.

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Phones

Named smartphones Xiaomi, Redmi and Poco, which will receive MIUI 13.5

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Named smartphones Xiaomi Redmi and Poco which will receive MIUI

A source specializing in leaks about Xiaomi smartphones has published a list of the company’s models that will receive the MIUI 13.5 interface. Alas, not very good news for users of many Xiaomi, Redmi and Poco smartphones, whose devices have only been updated to Android 11: these models will not receive MIUI 13.5.

Named smartphones Xiaomi, Redmi and Poco, which will receive MIUI 13.5

The list of such smartphones is as follows:

  • Mi 9, 9 SE, 9 Lite, 9 Pro;
  • Mi 9T, Mi 9T Pro;
  • Mi CC9, Mi CC9 Meitu;
  • Redmi K20, K20 Pro, K20 Pro Premium;
  • Redmi Note 8, Note 8T, Note 8 Pro;
  • Redmi 9A, 9AT, 9i, 9C;
  • POCO C3, C31.

And here are the lists of models that will receive the MIUI 13.5 update. The source broke them down into brands:

Xiaomi:

  • Xiaomi 12;
  • Xiaomi 12 Pro;
  • Xiaomi 12X;
  • Xiaomi 12 Ultra;
  • Xiaomi 12 Lite;
  • Xiaomi 11T;
  • Xiaomi 11T Pro;
  • Xiaomi Mi 11 Lite 4G;
  • Xiaomi Mi 11 Lite 5G;
  • Xiaomi 11 Lite 5G NE;
  • Xiaomi Mi 11;
  • Xiaomi Mi 11i;
  • Xiaomi Mi 11 Ultra;
  • Xiaomi Mi 11 Pro;
  • Xiaomi Mi 11X Pro;
  • Xiaomi Mix 4;
  • Xiaomi Mix Fold;
  • Xiaomi MIX Fold 2;
  • Xiaomi Civi;
  • Xiaomi Civi 1S;
  • Xiaomi Mi Note 10 Lite;
  • Xiaomi Mi 10;
  • Xiaomi Mi 10 Pro;
  • Xiaomi Mi 10 Lite;
  • Xiaomi Mi 10 Lite Zoom;
  • Xiaomi Mi 10 Ultra;
  • Xiaomi Mi 10T;
  • Xiaomi Mi 10T Lite.

Redmi:

  • Redmi Note 11;
  • Redmi Note 11 4G;
  • Redmi Note 11T;
  • Redmi Note 11 Pro;
  • Redmi Note 11 Pro+ 5G;
  • Redmi Note 11S;
  • Redmi Note 11 Pro;
  • Redmi Note 11 Pro 5G;
  • Redmi Note 10 Pro;
  • Redmi Note 10;
  • Redmi Note 10T (Japan);
  • Redmi Note 9 Pro 5G;
  • Redmi K50;
  • Redmi K50 Pro;
  • Redmi K50 Gaming;
  • Redmi K40S;
  • Redmi K40 Pro;
  • Redmi K40 Pro+;
  • Redmi K40;
  • Redmi K40 Gaming;
  • Redmi K30S Ultra;
  • Redmi K30 4G;
  • Redmi K30 Pro;
  • Redmi Note 8 2021;
  • Redmi Note 10 Pro 5G;
  • Redmi 10C;
  • Redmi 10A;
  • Redmi 10 Power;
  • Redmi 10;
  • Redmi 10 Prime;
  • Redmi 10 Prime 2022;
  • Redmi 10 2022;
  • Redmi Note 11E;
  • Redmi Note 11E Pro;
  • Redmi Note 11T Pro;
  • Redmi Note 11T Pro+.

Poco:

  • Poco M4 Pro 4G;
  • Poco M4;
  • Poco X4 Pro 5G;
  • Poco M4 Pro 5G;
  • Poco X3 Pro;
  • Poco X3 GT;
  • Poco X4 GT;
  • Poco X4 GT+;
  • Poco F4;
  • Poco F4 Pro;
  • Poco F3;
  • Poco F3 GT;
  • Poco C40;
  • Poco C40+.

As you can see, these lists are as up to date as possible – they include models that have not even been presented yet, like Redmi Note 11T Pro and Xiaomi 12 Ultra. But both MIUI 13.5 and MIUI 14 will definitely receive these new items, so including them in the lists of models for which MIUI 13.5 will be released is fully justified.

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